Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.
The human ether-a-go-go-related gene rowenta dr8270 (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes.Berberine (BBR) has multiple actions, and its hydrogenated derivative